Hippomedon was a name attributed to various characters in Greek mythology, but only one is prominent. This Hippomedon was one of the characters in the myth of the Seven Against Thebes. He was the son of Talaus and Metidice, although other sources give him different parents. He was one of the seven leaders who decided to attack the city of Thebes; on his shield was the depiction of Typhon, the father of all monsters. He was challenged by Hyperbius during his attack, but he was eventually killed by Ismarus, son of Astacus.
In a different version of his death, Hippomedon went on a killing spree during the battle while trying to take the body of Tydeus back from the Thebans. One of his victims was Crenaeus, son of Pan and the nymph Ismenis, daughter of the river god Ismenus. Thus, when Hippomedon stepped into the river, Ismenus raised the water level in order to drown him. However, Hippomedon begged not to die in this way and Zeus managed to convince the river god to spare him. As soon as Hippomedon stepped out of the river, though, he was attacked by the enemy and killed instantly.